One way is to simply study the normal cytokine cycle and determine how the components that are elevated in fatal cases (Neopterin, TNF, which is is indicative of Interferon breakdown ) can be regulated back to homeostatic controls.
As has been said previously, all disease is the result of the the removal of homeostatic controls in IL1. TNF NEGATIVE FEEDBACK inhibition. For the IL1 , IL6 , TNF-alpha to remain elevated implies that something is disallowing their being turned off
Here is an article for the strong in heart to help decipher this enigmatic problem
.http://bit.ly/1su2Jj0
Here is another article attempting to emphasize the importance of study of the pathways of inflammatory cytokines in order to understand how they can become pathogenic
http://bit.ly/1yHisQM
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